Oxidative Deamination of Sulfinyl, Sulfonyl and Thiosulfonyl Amino Acids by D-Aspartate Oxidase
نویسندگان
چکیده
منابع مشابه
Biological role of D-amino acid oxidase and D-aspartate oxidase. Effects of D-amino acids.
D-Amino acids administered to animals are absorbed by the intestine and transported through the blood-stream to solid tissues where they are oxidized in vivo by D-amino acid oxidase and D-aspartate oxidase to produce the same compounds they do in vitro; i.e. NH3, H2O2, and the keto acid corresponding to the amino acid ingested. In the liver and kidneys of the animals, an inverse relationship ex...
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The types of Clostridium botulinum were found to differ in their abilities to deaminate single amino acids. Cells were prepared from 24to 36-hr cultures grown at 37 C in screw-cap tubes in a medium containing (grams per liter); Trypticase (BBL), 15; Phytone (BBL), 5; yeast extract, 5; K2HP04, 8.5; KH2PO4, 1.5; NaCl, 1; MgSO4. 7H20, 0.25; FeSO4.7H20, 0.0125; and sodium thioglycolate, 1. The cell...
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Benzoate competes with n-amino acids for n-amino acid oxidase and thus inhibits the activity of the oxidase (l-3). Monosubstituted benzoates, depending upon the substituent, have higher and lower affinities for the oxidase than has benzoate (2). Kojic acid, a Y-pyrone, likewise competitively inhibits the oxidase (4). The present report describes the inhibition of n-amino acid oxidase by certain...
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Cell-free extracts prepared from rat kidney or liver catalyzed the oxidative deamination of S-adenosyl-Lhomocysteine to S-adenosyl-y-thio-a-ketobutyrate. This reaction was found to be catalyzed by L-amino acid oxidase (L-amino acid:oxygen oxidoreductase (deaminating), EC 1.4.3.2). In the presence of catalase, 0.48 pmole of oxygen was consumed for each micromole of substrate oxidized, and 1 pmol...
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D-Amino acid oxidases (DAAOs) have an important role in several processes of interest in the fine chemical and pharmaceutical industry for drug discovery. They are used in the production of optically pure L-amino acids1 and unnatural amino acids2, and the production of 7-aminocephalosporanic acid (7-ACA)2,3 which is a precursor of antibiotics with annual demand of approximately 100 t worldwide3...
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ژورنال
عنوان ژورنال: European Journal of Biochemistry
سال: 1972
ISSN: 0014-2956,1432-1033
DOI: 10.1111/j.1432-1033.1972.tb19708.x